Fig. 1.

Simulated pharmacokinetic (PK) parameters after a single dose of 20 mg teneligliptin in virtual Japanese and European descent populations. Age versus AUC_0–∞ (a) and C_max (b). Values are shown as the mean ± standard deviation for age and both PK parameters in the Japanese (20–70 years; red-filled squares) and European descent (20–98 years; blue-filled circles) populations. Age was divided into 5-year categories (4-year categories for those aged ≥ 90 years). AUC_0–∞ Area under the plasma concentration–time curve from 0 h to infinity, C_max maximum plasma concentration