Table 1.
Observed and simulated pharmacokinetic parameters in Japanese subjects
| PK parameters | Observed [34]a | Simulatedb | Ratio (simulated/observed) |
|---|---|---|---|
| AUC0–24h (ng·h/mL) | 1625.1 (352.8) | 2183.9 (1068.5) | 1.34 |
| Cmax (ng/mL) | 274.5 (57.4) | 202.9 (137.9) | 0.74 |
Data are mean (SD) unless otherwise stated.
AUC0–24h Area under the plasma concentration–time curve from 0 to 24 h, Cmax maximum plasma concentration, PK pharmacokinetic, SD standard deviation
aMean (SD) age: 57.1 (8.7) years [n = 33]
bMean (SD) age: 56.2 (8.6) years [n = 320]