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. 2024 Jan 18;130(6):908–924. doi: 10.1038/s41416-023-02522-5

Fig. 6. p63 regulates the partial EMT and MET state in primary tumour and distant metastases.

Fig. 6

a TF-TGs analysis using the Dorothea database shows abundant enrichment of Trp63 target genes in lung mets. b Violin plots show p63 upregulation in cluster 2 relative to all other clusters when comparing lung mets to primary GPx2KD tumour. c–e Multiplex staining for KRT8 (purple), KRT14 (red), p63 (green) revealed that individual and overlay staining on control PyMT1 tumours (n = 8), PyMT1/GPx2 KD tumours (n = 8), and paired lung mets (4 independent lungs from 4 GPx2 KD tumour bearing mice). f, g Graphs display percentage of p63 positive cells that also expressed KRT8, KRT8/KRT14, or KRT14 in primary GPx2KD tumours (f) or lung mets (g); Mean ± SEM; ****p < 0.0001.