Fig. 2. RNA-seq reveals CMV infection of cerebral organoids dysregulates cellular pluripotency and differentiation.

a De-convolution analysis revealing the different cellular populations in generated cerebral organoids. b Downregulated DEGs with an FDR cut-off in CMV-infected cerebral organoids relative to mock were over-represented in the GO terms associated with cellular differentiation. c Heatmap of KEGG signalling pathways regulating pluripotency of stem cells (hsa04550) displaying genes upregulated and downregulated in CMV-infected compared to mock-infected organoids. See also Supplementary Data 1, Supplementary Data 2, and Supplementary Data 3.