Table 1.

Pharmacokinetic parameters of Nicotine CVE (Fig. 2).

	Inter-vape interval
Parameter	5 min(+)	10 min(*)	15 min(#)	60 min(^)
AUC (ng*hr/ml)	661 ± 60####,^^^^	488 ± 39####,^^^^	300 ± 14^^^^	135 ± 6
Cmax (ng/ml)	155 ± 11	83 ± 21	24 ± 3	13 ± 0.9
t1/2 (min)	5.8	8.1	15.1	19.8

AUC, the area under the plasma concentration–time curve from t = 0 to t = 24 h;

C_max, maximum observed plasma concentration; t_1/2, half-life. ****P < 0.0001 vs. VEH by two-way.

Repeated measures ANOVA followed by Tukey post-hoc. n = 7 per group.