Table 1.
Mendelian randomization (MR) results for inverse variance weighted (IVW), weighted median, and MR- Egger methods.
| MR method | beta | SE | p-value | N SNPs | OR | 95％CI | |
|---|---|---|---|---|---|---|---|
| BMI→ UA |
IVW | 0.187 | 0.040 | 3.45E-06 | 21 | 1.206 | 1.114–1.305 |
| Weighted median | 0.160 | 0.045 | 3.67E-04 | 21 | 1.173 | 1.075–1.281 | |
| MR-Egger | 0.081 | 0.147 | 5.86E-01 | 21 | 1.085 | 0.814–1.447 | |
| UA→ BMI |
IVW | −0.005 | 0.018 | 0.776 | 78 | 0.995 | 0.961–1.030 |
| Weighted median | −0.034 | 0.020 | 0.076 | 78 | 0.966 | 0.930–1.004 | |
| MR-Egger | −0.075 | 0.029 | 0.011 | 78 | 0.928 | 0.877–0.982 |
BMI, Body mass index (BMI); SE, standard error; SNP, single nucleotide polymorphism; N SNP, number of single nucleotide polymorphism; IVW, inverse variance weighted; CI, confidence interval. OR, odds ratio.