Figure 6.

Significant taxonomic changes predicted by MaAsLin2 observed in viroimmunotherapy-treated mice with CD4⁺ T cell depletion

The phyla Actinobacteria (FDR p = 3.073e−02) (A), characterized by the genus Bifidobacterium (C), and Verrucomicrobia (FDR p = 3.073e−02) (B), highlighted by the genus Akkermansia (FDR p = 9.691e−02) (D), were decreased in the gut microbiota of mice treated with the oncolytic virus and the IDO inhibitor when having depleted CD4⁺ T cells. Other reduced biomarkers at the genus level of this group included Lactobacillus (FDR p = 1.093e−01) (E), Ruminococcaceae UCG 014 (FDR p = 1.623e−01) (F), Muribaculum (FDR p = 4.934e−03) (G), and Lachnospiraceae A2 (FDR p = 1.623e−01) (H).