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. 2024 Mar 20;28(7):e18213. doi: 10.1111/jcmm.18213

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© 2024 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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YARS1 interacts with MYC to regulate ferroptosis, senescence and stemness in bladder cancer cells. (A) Identification of ferroptosis and cellular senescence‐related prognostic genes. (B) Analysis of ferroptosis and cellular senescence‐related prognostic genes correlating with YARS1. (C) Differential analysis of ferroptosis and cell senescence‐related prognostic genes in high YARS1 expression group and low YARS1 expression group. (D) Interaction network of YARS1. (E) Molecular docking of YARS1 with MYC. (F) MYC regulates the promoter activity of YARS1. (G, H) YARS1 positively correlates with bladder cancer stemness score. (I) Heat map of bladder cancer stemness score. *p < .05, **p < .01, ***p < .001.