Table 2. Overview of the GENOMARK and TGx-DDI Hazard Classifications Based on Gene Expression Data Obtained with TempO-Seq^a.

^aChemicals (GLY, MMS, NDMA, 4NQO, AFB1, COL, CPA, MMC, 2CTAC, and EUG) are listed in increasing test concentrations (C1–C4/C5) with their corresponding in vivo genotoxicity data. For GENOMARK, the individual prediction scores of the RF and SVM model are given together with the overall classification result for genotoxicity. A probability result <0.45 is considered nongenotoxic (NGTX) (green), ≥0.45 and ≤0.55 inconclusive (INCONCL) (yellow), and >0.55 genotoxic (GTX) (red). For TGx-DDI, classification, the results of the individual statistical analyses (NSC-PA, PCA, and HC) for direct DNA damaging (DDI, in red) or nondirect DNA damaging (non-DDI, in green) and the overall classification result are provided. *Excluded for transcriptome analysis due to overtly cytotoxic in QA/QC.