Figure 6.

Emergence of photoreceptor and bipolar cells via T1 and T3 neurogenic progenitors

(A) UMAP plot showing selected cluster of integrated scRNA-seq (Table S4) used for pseudotime analyses. Highly expressed marker genes for each cluster along the pseudotime trajectory are shown in Table S4.

(B and C) Pseudotime analysis revealing transition from pCM to RPCs, T1 and T3, further giving rise to cone and rod photoreceptors and bipolar cells.

(D) Gene expression heatmap revealing distinct expression patterns of T1 and T3 progenitors and photoreceptors, while BCPs display transcriptional similarity with transient neurogenic cells, T1 and T3, suggesting the lack of mature bipolar cells in ROs.

Related to Table S4.