Fig. 1.

Schematic diagram of the human and mouse HDAC7 proteins. Schematic diagrams of the human HDAC7 protein (hHDAC7) (A) and the mouse Hdac7 protein (mHdac7) isoforms that are generated by alternative splicing (B). Hdac7‐spliced (Hdac7‐s) is a full‐length protein generated after excision of a 57 bp intron region. This intron is retained in the Hdac7‐unspliced (Hdac7‐u) isoform, resulting in the presence of premature start codons and use of an alternate downstream translation start site. Consequently, Hdac7‐u lacks the first 22 N‐terminal amino acids (and a binding site for the transcriptional repressor CtBP) that are present in Hdac7‐s. Serine (S) residues that regulate HDAC7 nuclear/cytoplasmic shuttling, as well as a histidine (H) residue that is essential for enzymatic activity, are indicated in yellow and are numbered in the context of the indicated protein (e.g. S178 in mHdac7‐s corresponds to S156 in mHdac7‐u). Proteins used for amino acid numbering are NM_001098416.4 (hHDAC7), NP_062518.2 (mHdac7‐s) and NP_001191207.1 (mHdac7‐u). MEF2, binding site for members of the MEF2 transcription factor family; CtBP, binding site for C‐terminal binding protein; NLS, nuclear localisation signal; NES, nuclear export signal.