Fig. 3.

Roles of HDAC7 in physiological and pathophysiological processes. (A) HDAC7 regulates the functions of many cell types in response to a range of differentiation and/or activation signals (see Table 1 for specific transcription factors involved). This class IIa HDAC regulates cell fate choices during both T cell and B cell development, as well as vascular formation and angiogenesis during embryonic development. It also controls the functions and stress responses of cardiomyocytes, as well as metabolic and inflammatory responses in innate immune cells. (B) Because of its diverse physiological roles, dysregulated expression and/or function of HDAC7 has been implicated in numerous pathologies. These include cancer (both solid tumours and leukaemias), as well as inflammatory and metabolic diseases that affect the liver, digestive systems, lung and joints. In contrast, HDAC7 may have a protective role in limiting neurodegenerative disease progression in Huntington's disease (labelled in blue). PSC, primary sclerosing cholangitis.