FIG. 5.

CTL activity in H25 and HL25 transgenic mice. H25 and HL25 transgenic mice and transgene-negative control (ctrl) littermates were infected i.v. with 200 PFU of LCMV-WE. Eight days later, spleen cells were tested for cytolytic activity in a 5-h ⁵¹Cr release assay. MC57G target cells were labeled with the LCMV-specific peptide GP33-41 or NP396-408 or an irrelevant, H-2D^b-binding adenovirus (Adeno) peptide. Percentages of specific lysis by splenic effectors of individual mice are plotted at the indicated effector/target (E/T) ratios. Spontaneous release was below 17%. Values are for individual mice from one representative experiment of three similar experiments.