Table 5.
Association of change in body mass index (BMI) between baseline and 4–5 years’ follow‐up and the odds of progression of definite overall structural defects of hip osteoarthritis (OA), as well as degeneration of individual structural features of the hip, as shown in univariate and multivariable analyses*
| Outcome | OAI univariate analysis | OAI multivariable analysis† | CHECK univariate analysis | CHECK multivariable analysis† | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Progression of definite overall structural defects of hip OA | No observation | – | No observation | – | 0.85 (0.50–1.44) | 0.55 | 0.73 (0.38–1.41) | 0.35 |
| Degeneration of individual structural features of the hip (as investigated in the progression cohorts) | ||||||||
| Joint space narrowing lateral | 1.11 (0.90–1.37) | 0.33 | 1.11 (0.90–1.37) | 0.32 | 0.94 (0.66–1.35) | 0.75 | 0.95 (0.66–1.36) | 0.76 |
| Joint space narrowing medial | 0.85 (0.70–1.03) | 0.09 | 0.86 (0.71–1.04) | 0.12 | 0.88 (0.61–1.27) | 0.51 | 0.90 (0.61–1.32) | 0.58 |
| Osteophytes acetabular superior | 0.91 (0.71–1.17) | 0.47 | 0.92 (0.71–1.18) | 0.50 | 0.79 (0.59–1.06) | 0.11 | 0.77 (0.57–1.05) | 0.10 |
| Osteophytes acetabular inferior | 0.81 (0.61–1.08) | 0.15 | 0.82 (0.61–1.09) | 0.17 | 0.85 (0.60–1.21) | 0.36 | 0.85 (0.60–1.20) | 0.35 |
| Osteophytes femoral superior | 1.26 (0.98–1.61) | 0.07 | 1.27 (0.99–1.64) | 0.06 | 0.84 (0.65–1.09) | 0.19 | 0.85 (0.66–1.10) | 0.23 |
| Osteophytes femoral inferior | 0.89 (0.70–1.13) | 0.33 | 0.89 (0.70–1.13) | 0.33 | 1.10 (0.91–1.33) | 0.31 | 1.09 (0.90–1.32) | 0.39 |
| By sum of osteophyte scores | 1.10 (0.86–1.40) | 0.44 | 1.10 (0.87–1.41) | 0.42 | 0.94 (0.75–1.18) | 0.59 | 0.93 (0.74–1.17) | 0.54 |
| Subchondral cysts acetabular | 0.69 (0.46–1.03) | 0.07 | 0.65 (0.42–1.01) | 0.06 | 0.94 (0.28 3.19) | 0.92 | Insufficient observations | – |
| Subchondral sclerosis femoral | 0.93 (0.65–1.33) | 0.69 | 0.96 (0.67–1.36) | 0.80 | 0.94 (0.50–1.75) | 0.84 | 0.88 (0.44–1.77) | 0.72 |
| Femoral head deformity | 0.54 (0.29–1.00) | 0.05 | 0.56 (0.28–1.12) | 0.10 | 0.51 (0.20–1.31) | 0.16 | 0.41 (0.11–1.49) | 0.18 |
*
The estimates are reported as point estimates of a 1 BMI–unit (kg/m2) increase from baseline to 4–5 years’ follow‐up. 95% CI = 95% confidence interval; CHECK = Cohort Hip and Cohort Knee (study); OAI = Osteoarthritis Initiative; OR = odds ratio.
†
The multivariable analysis was adjusted for age at baseline, sex, and BMI at baseline.