Skip to main content
. 2023 Jul 14;78(11):2980–2993. doi: 10.1111/all.15814

FIGURE 3.

FIGURE 3

In vitro priming of drug‐specific T cells in drug‐naïve healthy individuals. Repeated drug exposure of PBMCs derived from drug‐naïve HLA‐B*58:01‐positive (black circles) or–B*58:01‐negative (white circles) individuals was performed to determine expansion and functionality of drug‐specific T cells. Individual data (n = 12) are shown as group data (bar = mean). Drug stimulation rounds were R1 (d12‐15 T cells), R2 (d22‐29 T cells) and R3 (d41‐43 T cells). APC represented by C1R.B*58:01. Statistical analysis was performed with a paired t‐test (two‐tailed) with significance denoted as *p < .05.