TABLE 1.
Study cohort HLA and drug hypersensitivity information.
| Study ID | HLA‐B | ALP exposure | cADR | Collection date | Time post‐reaction |
|---|---|---|---|---|---|
| CU001 | 58:01 | No | No | 13/10/2010 | ‐ |
| CU002 | 58:01 | Yes | SJS | 29/09/2010 | 4 years |
| CU003 | 58:01 | Yes | SJS | 27/09/2010 | 6 years |
| CU004 | 58:01 | No | No | 13/10/2010 | ‐ |
| CU005 | 58:01 | Yes | TEN | 28/09/2010 | 5 years |
| CU006 | 58:01 | Yes | SJS | 10/04/2010 | 7 years |
| AP012 | 57:01, 58:01 | No | No | 23/07/2014 | ‐ |
| AP013 | 15:01, 58:01 | No | No | 24/07/2014 | ‐ |
| AP014 | 41:01, 58:01 | No | No | 30/07/2014 | ‐ |
| AP015 | 40:06, 58:01 | No | No | 31/07/2014 | ‐ |
| AP016 | 27:04, 58:01 | No | No | 13/08/2014 | ‐ |
| AP018 | 39:24, 58:01 | No | No | 27/08/2014 | ‐ |
| AP025 | 07:02, 58:01 | No | No | 22/09/2014 | ‐ |
| AP027 | 15:02, 58 | No | No | 30/09/2014 | ‐ |
| AP101 | 44, 58 | No | No | 12/03/2014 | ‐ |
| AP105 | 7, 8 | No | No | 20/03/2014 | ‐ |
| AP108 | 14:01, 51:01 | No | No | 31/03/2014 | ‐ |
| AP111 | 44, 57 | No | No | 18/06/2014 | ‐ |
Note: Patients are denoted as CU and healthy participants are denoted as AP. For CU patients, it is unknown whether HLA‐B*58:01 is homozygous or heterozygous.
Abbreviations: cADR, cutaneous adverse drug reaction; SJS, Stevens–Johnson syndrome; TEN, toxic epidermal necrolysis.