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. 2023 Apr 6;113(6):1304–1314. doi: 10.1002/cpt.2888

Figure 2.

Figure 2

ROC analysis of the ability of APAP metabolite concentration, ALT and metabolite ratios to predict hepatotoxicity. ROC analysis of the ability of (a) initial APAP metabolite concentrations (b) ALT, APAP‐Cys/APAP‐Sul and APAP‐Cys/APAP‐Sul*ALT (c) Forest plot of AUC‐ROC to predict hepatotoxicity (ALT >1,000 U/L) (squares) and ALT >100 U/L (open circles). ALT, alanine aminotransferase; APAP, acetaminophen; APAP‐Cys, acetaminophen‐cysteine; APAP‐Glu, acetaminophen‐glucuronide; APAP‐Mer, acetaminophen‐mercapturate; APAP‐Sul, acetaminophen‐sulfate; AUC, area under the curve; CI, confidence interval; ROC, receiver operating characteristic curve.