Table 4.
Correlation (R value) between APAP‐Cys, APAP‐Sul, % CYP metabolites (CYP metabolites/total metabolites) and risk factors for liver injury and outcomes
| APAP‐Cys | APAP‐Sul | % CYP metabolites | APAP‐Cys/APAP‐Sul | |
|---|---|---|---|---|
| R value (95% CI) | R value (95% CI) | R value (95% CI) | R value (95% CI) | |
| (n = 200) | (n = 200) | (n = 200) | (n = 200) | |
| Risk factors | ||||
|
Dose (mg/kg)b (n = 197) |
0.26 (0.13 to 0.39) | 0.19 (0.05 to 0.32) | −0.08 (−0.22 to 0.07) | 0.09 (−0.05 to 0.23) |
|
Agea (n = 200) |
0.08 (−0.07 to 0.22) | 0.29 (0.15 to 0.41) | −0.02 (−0.17 to 0.12) | −0.09 (−0.23 to 0.05) |
|
Time post ingestiona (n = 200) |
0.45 (0.32 to 0.55) | −0.28 (−0.41 to −0.14) | 0.49 (0.38 to 0.60) | 0.49 (0.38 to 0.59) |
|
Acetaminophen ratiob (n = 200) |
0.61 (0.52 to 0.69) | 0.004 (−0.13 to 0.14) | 0.19 (0.06 to 0.32) | 0.40 (0.27 to 0.51) |
| Outcomes | ||||
|
Peak ALTa (n = 199) |
0.39 (0.26 to 0.50) | −0.14 (−0.28 to 0.00) | 0.36 (0.23 to 0.48) | 0.34 (0.21 to 0.46) |
|
Peak INRa (n = 165) |
0.47 (0.34 to 0.59) | −0.27 (−0.41 to −0.12) | 0.50 (0.38 to 0.61) | 0.38 (0.51 to 0.62) |
a
Spearman R correlation.
b
Pearson R correlation.