Table 2.
Baseline characteristics of participant*
| Characteristic | Total population, N = 1399 | Placebo‐only population, n = 621 | Placebo only (glucocorticoid trials group), n = 181 | Placebo only (hyaluronic acid trials group), n = 458 |
|---|---|---|---|---|
| Age, y, mean (SD) | 62.66 (10.57) | 62.07 (10.82) | 65.08 (10.77) | 60.90 (10.65) |
| Female sex, n (%) | 842 (60.1) | 361 (58.1) | 89 (49.2) | 284 (62.0) |
| BMI, kg/m2, mean (SD) | 28.88 (4.52)† | 29.27 (4.54)‡ | 29.38 (4.56)§ | 29.03 (4.08) |
| Duration of symptoms, mean (SD), mon | 44.49 (71.66)¶ | 78.07 (79.59)# | 85.29 (106.87)** | 66.79 (36.23)†† |
| KL grade, n % | ||||
| 0 | 2 (0.1) | 1 (0.2) | 1 (0.6) | 0 (0.0) |
| 1 | 60 (4.3) | 22 (3.5) | 4 (2.2) | 21 (4.6) |
| 2 | 513 (36.7) | 217 (34.9) | 27 (14.9) | 194 (42.4) |
| 3 | 657 (47.0) | 283 (45.5) | 75 (41.4) | 218 (47.6) |
| 4 | 83 (5.9) | 35 (5.6) | 34 (18.8) | 1 (0.2) |
| Missing | 84 (6.0) | 64 (10.3) | 40 (22.1) | 24 (5.2) |
| Inflammation, n (%) | 481 (51.2)§§ | 259 (45.2)¶¶ | 113 (71.97)## | 88 (28.9)*** |
| Effusion, n (%) | 306 (35.5)††† | 168 (30.4)‡‡‡ | 96 (70.07)§§§ | 40 (13.9)¶¶¶ |
| Pain (0–100), mean (SD) | 60.32 (18.30) | 61.85 (17.04) | 55.78 (19.86) | 65.53 (14.25) |
| Severe pain (≥70 points on VAS), n (%) | 293 (28.1)### | 179 (29.0)**** | 49 (27.53)†††† | 137 (29.9) |
| OA other joints, n (%) | 373 (58.5)‡‡‡‡ | 275 (57.9)§§§§ | 6 (21.43)¶¶¶¶ | 194 (67.6)#### |
BMI, body mass index; KL, Kellgren‐Lawrence; OA, osteoarthritis; VAS, visual analog scale.
N = 1,162 (not available for Lambert and Chao).
N = 561 (not available for Lambert and Chao).
N = 121 (not available for Lambert and Chao).
N = 1,223 (not available for Henriksen, Hall, Dahlberg).
N = 433.
N = 101.
N = 350.
N = 939 (not available for Lambert and Dahlberg and there are only placebo data for inflammation for Strand and Takamura).
N = 537.
N = 157.
N = 305 (not available for Dahlberg).
N = 861 (not available for Lambert and Dahlberg and there are only placebo data for inflammation for Strand and Takamura).
N = 553.
N = 137.
N = 287.
N = 1,043 (only have placebo data for Strand and Takamura).
N = 618.
N = 178.
N = 638 (not available for Lambert, Hall, Henriksen, Dahlberg, Chao, or Atchia).
N = 444 (not available for Lambert, Hall, Henriksen, Dahlberg, Chao, or Atchia).
N = 28 (not available for Lambert, Hall, Henriksen, Chao, or Atchia).
N = 287.