TABLE 1.
Baseline demographics and disease severity in those recruited to the COVRAS trial and randomized to either control arm or TVR027
| Full analysis set | Incomplete analysis set | |||
|---|---|---|---|---|
| Control (n = 11) | TRV027 (n = 10) | Control (n = 13) | TRV027 (n = 15) | |
| Median (range) or (%) | Median (range) or (%) | Median (range) or (%) | Median (range) or (%) | |
| Age (years) | 72 (43–79) | 70.5 (47–89) | 70.0 (43–79) | 67.0 (47–89) |
| Age group | ||||
| <60 | 4 (36.4) | 2 (20.0) | 6 (46.2) | 6 (40.0) |
| 60–69 | 0 | 2 (20.0) | 0 | 2 (13.3) |
| >69 | 7 (63.6) | 6 (60.0) | 7 (53.8) | 7 (46.7) |
| Gender | ||||
| Male | 3 (27.3) | 4 (40.0) | 4 (30.8) | 8 (53.3) |
| Female | 8 (72.7) | 6 (60.0) | 9 (69.2) | 7 (46.7) |
| Ethnicity | ||||
| White | 2 (18.2) | 4 (40.0) | 2 (15.4) | 5 (33.3) |
| Mixed | 0 (0) | 0 (0) | 0 (0) | 1 (6.7) |
| Asian | 3 (27.3) | 0 (0) | 3 (23.1) | 0 (0) |
| Black | 2 (18.2) | 0 (0) | 2 (15.4) | 0 (0) |
| Other | 4 (36.4) | 5 (50.0) | 5 (38.5) | 7 (46.7) |
| Not reported | 0 (0) | 1 (10.0) | 1 (7.7) | 2 (13.3) |
| Disease severity | ||||
| Mild | 3 (27.3) | 0 (0) | 3 (23.1) | 1 (6.7) |
| Moderate | 0 (0) | 1 (10.0) | 0 | 1 (6.7) |
| Severe | 5 (45.4) | 1 (10.0) | 7 (53.8) | 5 (33.3) |
| Critical | 3 (27.3) | 8 (80.0) | 3 (23.1) | 8 (53.3) |
Note: Data are presented for the full analysis set who received at least two infusions and had blood samples taken on Day 3 and the incomplete analysis set who were randomized but withdrawn before the primary endpoint.