TABLE 2.
Biochemical and clotting results from control and TRV027 arms with difference between baseline value (Day 1) and primary endpoint (Day 3) calculated
| Control (n = 11) | TRV027 (n = 10) | ||||
|---|---|---|---|---|---|
| n | Difference D3 – D1 | n | Difference D3 – D1 | P‐value | |
| D‐dimer | 8 | 96 | 10 | −129 | 0.15 |
| Platelets (×109/L) | 10 | 28.5 | 10 | 25 | 0.82 |
| aPTT (s) | 8 | −0.5 | 9 | −1.3 | 0.67 |
| Fibrinogen | 9 | −0.94 | 9 | −0.67 | 0.97 |
| Total bilirubin | 9 | 0 | 10 | −0.5 | 0.68 |
| LDH | 7 | 2 | 8 | −21.5 | 0.56 |
| Haptoglobin | 5 | 0.13 | 3 | 0 | 0.13 |
| Creatinine (umol/L) | 9 | −5 | 10 | −4 | 0.97 |
| BNP | 6 | −23.5 | 5 | 98 | 0.028 |
| Troponin | 6 | −2.5 | 6 | −2.5 | 0.51 |
| Ferritin | 8 | −14 | 10 | 52.5 | 0.48 |
| Pro‐calcitonin | 7 | 0 | 5 | 0 | 0.57 |
| Glucose (mmol/L) | 6 | 0 | 5 | −1.1 | 0.52 |