Fig. 5.

Concentration dependence of MAO‐B inhibition by SCRA compounds. (A) Concentration dependence of SCRA compounds 1–3 versus rate of MAO‐B turnover at 25 °C. Solid lines are the fit of the data to Eqn (2). (B) Concentration dependence of compounds 6–10 versus rate of MAO‐B turnover at 25 °C. Solid lines are the fit of the data to Eqn (2). (C) Resulting IC₅₀ values depicting the inhibition potency of compounds 6–10. Conditions, 30 μm MAO‐B, 1.5 mm BZA, 50 mm HEPES, pH 7.5 + 0.5% Triton X‐100, All data were collected in triplicate and error bars indicate standard error.