Fig. 6.

Concentration dependence of MAO‐A inhibition by SCRA compounds. MAO‐A turnover in the presence of three SCRA compounds. (A) Concentration dependence of SCRA compounds 1,3,5 versus rate of MAO‐A turnover at 25 °C. Solid lines are the fit of the data to Eqn (2), dashed lines are fit of corresponding MAO‐B data. (B) Resulting IC₅₀ values depicting the inhibition potency of SCRA compounds 1,3,5, with the corresponding IC₅₀ values for MAO‐B shown in pastel. Conditions, 20 μm MAO‐A, 1 mm KYN, 50 mm HEPES, pH 7.5 + 0.5% Triton X‐100, All data were collected in triplicate and error bars indicate standard error.