FIGURE 1.
GluN1 missense variants. (A) Schematic representation of the GluN1/2A N‐methyl‐d‐aspartate receptor in the agonist‐bound state showing the overall subunit arrangement and the position of the three GluN1 variants. (B) Expanded views of the boxed areas in A showing the amino acid substitutions as red spheres. The schematics were made in Visual Molecular Dynamics software using the 7EOS PDB file. 1 (C) Segments of amino acid sequences that encompass the three variants showing the sequence identity between the GluN1 and GluN2 subunits. The substituted positions in the GluN1‐3b subunit are shown in red. The M3 transmembrane domain is highlighted in blue, and the contiguous segment that is a key signal transduction element is highlighted in green.