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. 2023 Oct 17;64(12):3377–3388. doi: 10.1111/epi.17776

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© 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Single‐receptor currents. (A–C) Representative single‐receptor currents recorded from excised outside‐out membrane patches expressing the WT GluN1/2A (A), GluN1(A666S)/2A (B), and GluN1(Y668H)/2A (C). Expanded views of single‐receptor activity are shown on the left. (D) Quantification of unitary current for the indicated receptors. Note that the GluN1(Y668H)/2A variant receptors have a wild‐type‐like amplitude (large [L]) and two smaller amplitudes (small [S] and medium [M]). (E) Plots of discrete activations (active periods) of single‐receptor current for the indicated receptors. (F) Plots of the open state occupancy (P_O) within active periods for the indicated receptors. ***p < .001, ****p < .0001.