Table 2.
Association of NVP with genomic loci meeting significance thresholds at the discovery stage
| Discovery stage (JPA NEO) | Replication stage (JPAv2) | Meta-analysis | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cytoband | Sentinel SNP | Position (hg19) | Gene | Function | Ref | Alt | AF1 | β (SE) | p-value | AF1 | β (SE) | p-value | p-value | Direction | ||
| Binary 2 | ||||||||||||||||
| 19p13.11 | rs749451 | 19:18479647 | PGPEP1 | UTR3 | T | C | 0.49 | 0.184 (0.032) | 8.04E-09 | 0.49 | 0.202 (0.031) | 1.16E-10 | 5.55E-18 | + + | ||
| Binary 4 | ||||||||||||||||
| 11q22.1 | rs77775955 | 11:101247714 | PGR-AS1, TRPC6 | intergenic | G | A | 0.56 | −0.392 (0.063) | 5.54E-10 | 0.53 | −0.182 (0.064) | 4.46E-03 | 1.42E-10 | − − | ||
| Continuous | ||||||||||||||||
| 11q22.1 | rs77775955 | 11:101247714 | PGR-AS1, TRPC6 | intergenic | G | A | 0.55 | −0.090 (0.014) | 3.89E-11 | 0.55 | −0.046 (0.013) | 4.11E-04 | 9.75E-13 | − − | ||
| 19p13.11 | rs28568614 | 19:18479019 | PGPEP1 | UTR3 | A | G | 0.49 | 0.085 (0.014) | 4.54E-10 | 0.48 | 0.091 (0.013) | 1.87E-12 | 5.66E-21 | + + | ||
AF1, allele 1 frequency; Alt, alternative allele; β, regression coefficient; JPA NEO, Axiom Japonica Array NEO; JPAv2, Axiom Japonica Array v2; NVP, nausea and vomiting of pregnancy; Ref, reference allele; SE, standard error, SNP, single nucleotide polymorphism; UTR, untranslated region