Table 3.
Association of NVP with genomic loci meeting significance thresholds at the replication stage
| Discovery stage (JPA NEO) | Replication stage (JPAv2) | Meta-analysis | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cytoband | Sentinel SNP | Position (hg19) | Gene | Function | Ref | Alt | AF1 | β (SE) | p-value | AF1 | β (SE) | p-value | p-value | Direction | ||
| Binary 2 | ||||||||||||||||
| 19p13.11 | rs749451 | 19:18479647 | PGPEP1 | UTR3 | T | C | 0.49 | 0.184 (0.032) | 8.04E-09 | 0.49 | 0.202 (0.031) | 1.16E-10 | 5.546E-18 | ++ | ||
| 8q21.3 | rs149783780 | 8:90026699 | - | - | CAAAA | CA | 0.01 | -0.042 (0.145) | 7.73E-01 | 0.01 | 0.833 (0.145) | 1.00E-08 | 8.95E-05 | -+ | ||
| 11q11 | rs2867907 | 11:55170876 | OR4A15, OR4C15 | Intergenic | C | T | 0.50 | -0.017 (0.033) | 6.09E-01 | 0.50 | -0.178 (0.032) | 3.87E-08 | 1.73.E-05 | -- | ||
| Binary 3 | ||||||||||||||||
| 4q25 | rs75393668 | 4:108157443 | DKK2, PAPSS1 | Intergenic | T | C | 0.91 | 0.121 (0.088) | 1.69E-01 | 0.91 | -0.542 (0.091) | 2.80.E-09 | 8.96E-04 | +- | ||
| Binary 4 | ||||||||||||||||
| 19p13.11 | rs749451 | 19:18479647 | PGPEP1 | UTR3 | T | C | 0.50 | 0.312 (0.063) | 6.17E-07 | 0.49 | 0.373 (0.064) | 4.61E-09 | 1.80E-14 | ++ | ||
| Continuous | ||||||||||||||||
| 19p13.11 | rs749451 | 19:18479647 | PGPEP1 | UTR3 | T | C | 0.49 | 0.084 (0.014) | 5.97E-10 | 0.49 | 0.092 (0.013) | 1.08E-12 | 4.42E-21 | ++ | ||
AF1, allele 1 frequency; Alt, alternative allele; β, regression coefficient; JPA NEO, Axiom Japonica Array NEO; JPAv2, Axiom Japonica Array v2; NVP, nausea and vomiting of pregnancy; Ref, reference allele; SE, standard error, SNP, single nucleotide polymorphism; UTR, untranslated region