Figure 5.

AFM imaging indicates Aβ₄₂ oligomers have a detergent‐like effect on the supported lipid bilayer, which is not seen for Aβ₄₂ monomer or fibrils. (A) AFM topographical image of lipid bilayer supported on mica surface. (B) AFM images are shown for mica‐supported lipid bilayers on exposure to Aβ₄₂ monomer. (C) Aβ₄₂ oligomers. (D) Aβ₄₂ fibrils. Scale bar 500 nm, height scale range 12 nm. (E) Percentage of bilayer coverage at the edge of a lipid bilayer, exposed to Aβ₄₂ monomer (green), oligomer (blue), and fibril (red). Each data point represents an average percentage of bilayer coverage within a 0.1×0.5‐μm region. There were 20 measurements per data point, measured across three separate mica‐supported lipid bilayer preparations. Error bars, S.E. Adapted from [25].