FIGURE 6.

SAHA combined with PENAO significantly delays NB tumour growth and induces apoptosis in vivo. (A) Kaplan‐Meier survival curves of Balb/c nude mice xenografted with SK‐N‐BE(2)‐C or (B) KELLY cells, post tumour formation and during the administration of Saline, SAHA (17.5 mg/kg), PENAO (20 mg/kg I.P.) or a combination of both for up to 42 days on a 5 day on/2 day off treatment schedule. P values are from log‐rank statistic tests between the combination and all other treatment groups. (C) Representative ×20 images, with ×40 images inset (×10 objective lens), of treated SK‐N‐BE(2)‐C or (D) KELLY xenograft tumour sections stained with Haematoxylin & Eosin (H&E), anti‐Cleaved Caspase 3 (CC3) or anti‐Ki67. CC3 and Ki67 stained sections are counterstained with Haematoxylin. Scale bars represent 20 μM