Table 1.

The seven stages of histopathological change after MI – Lodge‐Patch scale.

Stage	Description
I	Earliest changes where stretching and waviness of myocardial fibres are observed and these myocytes have eosinophilic cytoplasm and pyknosis
II	Coagulation necrosis of cardiomyocytes with haemorrhage or neutrophil infiltration, but without CD68+ macrophages
III	Coagulation necrosis of cardiomyocytes with infiltration of CD68+ macrophages in addition to neutrophils
IV	Early stage of granulation in which fragmented myocytes with coagulation necrosis, many CD68+ macrophages, a few neutrophils, and fibroblasts are found
V	Mature granulation tissue with CD68+ macrophages and fibroblasts, but without necrotic myocytes or neutrophils
VI	The stage of fibrosis with abundant myofibroblasts positive for smooth muscle actin, in which the interstitium is weakly stained blue by Azan–Mallory throughout the lesion
VII	The lesion is replaced with scar tissue with a decrease of myofibroblasts and uniformly stained blue by Azan–Mallory