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. 1998 Mar;72(3):2352–2363. doi: 10.1128/jvi.72.3.2352-2363.1998

FIG. 3.

FIG. 3

pR33 is a member of the chemokine receptor-like GCR family. To compare the sequences of UL33-like GCRs, chemokine receptors, and non-chemokine-binding GCRs, a phylogenetic tree was calculated. The tree is based on a multiple alignment of amino acid sequences that are colinear with the putative seventh transmembrane region (amino acids 288 to 307) of pR33 (Fig. 2). CLUSTAL W pairwise alignment (48) was set to BLOSUM30 protein weight matrix, gap open penalty = 10, and gap extension penalty = 0.1. Multiple alignment was set to BLOSUM series, gap opening penalty = 10, gap extension penalty = 0.05, delay divergent sequences = 0.4. The virus-encoded GCRs are indicated analogous to pR33; i.e., the ORF designation is preceded by a ’p’. CC-CK, C-C chemokine receptor; IL-8, interleukin-8 receptor; A1AA, αA1-adrenergic receptor (13); H. halobium BACR, Halobacterium halobium bacteriorhodopsin (30); CD97, cluster designation 97 (28); OPSD, rhodopsin (39); ACM1, M1 muscarinic acetylcholine receptor (3); D. discoideum CAR1, Dictyostelium discoideum cyclic AMP receptor 1 (31); S. cerevisiae STE2, Saccharomyces cerevisiae pheromone α-factor receptor (14); CASR, extracellular calcium-sensing receptor (2); FSHR, follicle-stimulating hormone receptor (37).