a, Each cartoon person represents 10 patients. Overall, 73% of patients had an impact on care, including 17 patients with a change in their diagnosis (blue and purple) and 29 patients receiving MTT (dark red) with 7 of these having a response (dark red with star). Created with Biorender. com. b, Treatment received by the 200 patients with therapeutically actionable alterations resulting in an iCat recommendation and sufficient treatment follow-up data to be eligible for assessment of MTT. Patients did not receive MTT because they either received no therapy (n = 46), were newly diagnosed and receiving initial treatment (n = 29) or MTT was not available (n = 23).