Table 2.

Influence of ancestry on drug response

Drug class	Drug	Ancestral differences	References
Antihypertensive	Lisinopril	Increased risk of stroke in African ancestry individuals, whereas no such effect was seen in non-Africans.	Wright et al. (2005)
	Beta-blockers and angiotensin-converting-enzyme (ACE) inhibitors	African ancestry individuals have poorer BP lowering response compared with non-Africans.	Seedat and Parag (1987); Cohn et al. (2004)
	Calcium channel blockers (CCBs)	African ancestry individuals showed better response to CCBs when compared with non-Africans.	Nguyen et al. (2009)
	ACE	African ancestry was associated with reduction in SBP and DBP response to ACE	Peck et al. (2013)
	Isosorbide-hydralazine (I-H)	African ancestry individuals benefited more from I-H than non-Africans.	Carson et al. (1999)
Lipid lowering	Statins	Higher level o-expression of OATP1B1 and OATP1B3 in Asians compared with Europeans.	Peng et al. (2015)
	Pravastatin	Higher AUC and Cmax was seen in European-Americans compared with African-Americans.	Ho et al. (2007)
	Propranolol	53%–76% clearance in Africans compared with Europeans.	Sowinski et al. (1996)