FIGURE 13.

Ingenuity Pathway Analysis activation z-scores of regulated pathways from KC ADM reversal organoids. Ingenuity Pathway Analysis z-scores of top upregulated pathways from KC ADM reversal organoids. The RNA sequencing data from KC mice acinar organoids treated for ADM reversal with the compounds indicated were analyzed by Ingenuity Pathway Analysis (IPA) for the class of upstream regulators. The top upstream regulators are ranked by z-score with those regulators that are activated in red and those inhibited in blue. The -log (p-value) are indicated for each gene.