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Selection criteria for compound validation. Summary of selection criteria applied to prioritize compounds for validation from ADM inhibition (wildtype mice organoids) and ADM reversal (Cre-mice organoids) screens. Cytotoxicity was evaluated by calcein AM staining. Compounds that overlapped in all three selection criteria (apicidin and chaetocin in ADM inhibition assay; chaetocin in ADM reversal assay) are shown in red and were prioritized for validation in dose response.
