TABLE 1.

Summary of observed behavior and compound targets of Cayman Epigenetic Screening Library showing distinct morphological effects on ducts in the ADM inhibition (clusters to ducts) and/or ADM reversal (reversing ducts to clusters) assays in comparison to vehicle control (0.5% DMSO).

Compound (1μM)	ADM inhibition	ADM reversal	Major drug target
Apicidin	Did not form ducts	Reduced duct sizes	HDACs (Zn2+ dependent), class I selective
LAQ824	Small ducts	No change	HDACs (Zn2+ dependent), class I selective
Chaetocin	Did not form ducts	Complete reversal to clusters	HMTs
Lestaurtinib	Small ducts	Reduced duct sizes	JAK2, STAT5, STAT3
B32B3	Did not form ducts	No change	VprBP
IBET762	Enlarged ducts	Reduced duct sizes	BETs
IBET151	Enlarged ducts	Reduced duct sizes	BETs
(+) JQ1	Enlarged ducts	Reduced duct sizes	BETs
PFI-1	Enlarged ducts	No change	BETs