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Diagrammatic representation of the ectodomain and membrane-spanning domain of the transmembrane glycoproteins of HIV-1 (LAI) and FIV (Wo) and alignment of the FIV TM3 peptide with an HIV-1 peptide comprising the 2F5 B-cell epitope. The TM3 epitope (QQLGEWED) best recognized during FIV infection and the 2F5 epitope (ELDKWA) are indicated. Symbols: ░⃞, fusion peptide; ▧, leucine zipper region; ▨, membrane-proximal α-helix; , membrane-spanning domain.
