TABLE 1.
Antibody response to peptides during immunization
| Group and cat no. | Anti-peptide
titera on day
of:
|
Immunoprecipitationb on day of challenge | ||
|---|---|---|---|---|
| 1st boost | 2nd boost | Challenge | ||
| SU2 | ||||
| 324 | 4.71 | 5.01 | 5.61 | + |
| 325 | 5.01 | 5.31 | 5.01 | + |
| 326 | 4.40 | 4.71 | 5.31 | − |
| 327 | 5.31 | 5.01 | 4.71 | + |
| SU5 | ||||
| 328 | 5.01 | 5.31 | 4.71 | + |
| 329 | 5.31 | 5.31 | 5.01 | + |
| 340 | 4.71 | 5.01 | 5.01 | + |
| 341 | >5.61 | 5.31 | 5.01 | + |
| TM3 | ||||
| 346 | 4.71 | 4.71 | 4.40 | + |
| 347 | 5.01 | 5.31 | 4.71 | + |
| 348 | 5.31 | 5.01 | 4.40 | − |
| 349 | NDc | 3.20 | 4.40 | − |
a
The titer was expressed as the logarithm of the reciprocal of the last serum dilution for which the absorbance at 405 nm was greater than 0.1.
b
Immunoprecipitation of envelope glycoproteins from metabolically labeled FL-4 cells (SU2 and SU5 groups) or acutely infected PBMC (TM3 group).
c
ND, not done.