Table 2.
Dolutegravir Pharmacokinetic Parameters
| Pharmacokinetic Parameter | Control Arm (n = 6) | Rifampicin Arm (n = 21) |
|---|---|---|
| Infants with Ctrough <0.32 mg/L | 0 (0%) | 1 (5%) |
| Infants with Ctrough <0.064 mg/L | 0 (0%) | 0 (0%) |
| Trough concentration, mg/L | 1.11 (46.3%) | 1.06 (82.4%) |
| Area under the plasma concentration-time curve over 24 h, h × mg/L | 54.42 (39.0%) | 49.78 (70.1%) |
| Maximum concentration, mg/L | 3.86 (37.7%) | 3.36 (65.4%) |
| Time to Cmax, h | 2.7 (50.7%) | 2.2 (25.1%) |
| Half-life, h | 12.33 (36.7%) | 5.97 (38.8%) |
| Apparent clearance, mL/min | 0.159 (31.7%) | 0.339 (59.4%) |
| Volume of distribution, L | 2.83 (21.9%) | 2.92 (69.3%) |
| Dolutegravir metabolic ratio | 0.0292 (50%) | 0.0667 (66%) |
Reported proportions or geometric mean (coefficient of variance). Abbreviation: Cmax, maximum concentration; Ctrough, trough concentration.