FIGURE 2.

Schematic concept of progression of disease in Metabolic Dysfunction Associated Steatotic Liver Disease. Disease progression depends intrahepatically on the balance between pro‐fibrogenic mechanisms and defence/repair mechanisms. Fibrosis is driven by upstream processes of damage and inflammation, which result from a metabolic pressure. An efficacious management of Metabolic Dysfunction Associated Steatohepatitis most likely needs to tackle these upstream drivers of disease to be successful. Adapted from. ¹