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. 2024 Mar 20;15:2493. doi: 10.1038/s41467-024-46840-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a A schematic diagram of the antihistamine design of H₄R, utilizing key information of E182/ligand interaction. b VUF5202 exhibits inverse agonist activity. Data are presented as mean values ± SEM.; n = 3 independent experiments for the binding assay (both Clobenpropit and VUF5202), n = 6 for Clobenpropit BRET assay, and n = 3 for VUF5202 BRET assay. Source data are provided as a Source Data file.