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. 2024 Mar 20;15:2486. doi: 10.1038/s41467-024-46703-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Readthrough measured by Dual-Luc assay (average of 4–7 replicates) vs. readthrough predicted by random forest model using CFTR PTC alleles in Dual-Luc reporter’s sequence. b Response to G418 treatment is defined as fold-change of readthrough in G418-treated to untreated condition from (a), measured vs. predicted. c Comparison of two readthrough prediction schemes: predicted using CFTR PTC allele in reporter’s sequence or predicted using CFTR PTC allele’s native sequence. d As in (a), but readthrough was predicted using CFTR PTC allele’s native sequence. e As in (b), but readthrough was predicted using CFTR PTC allele’s native sequence. For all panels, the two-tailed Spearman’s correlation coefficient (ρ) and the associated p-value is reported. Source data are provided as a Source Data file and Supplementary Data 1.