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The structure of the mTOR kinase domain and some common mutations. The most common mutations responsible for changes in the structure of mTOR kinase are highlighted in red. Abbreviations: HEAT repeats, Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), TOR1; FAT domain, FRAP, ATM, TRRAP; FRB domain, FKBP12-rapamycin binding; FATC domain, C-terminal FAT domain; other explanations in text.
