Table 1.
Characteristics of patients and treatments for cases with sepsis
| Variable | Sepsis-1, according to chart review | Sepsis-3, according to chart review | |||||
|---|---|---|---|---|---|---|---|
| N missing | Sepsis-1 | Severe Sepsis-1 | Septic shock-1 | N missing | Sepsis-3 | Septic shock-3 | |
| Statistic | Statistic | Statistic | Statistic | Statistic | |||
| N in sample | 1852 | 1310 | 879 | 1163 | 653 | ||
| Proportion of hospital admissions | 6.5% | 3.3% | 1.6% | 2.9% | 1.1% | ||
| Age | 0/1852 | 70 [58, 79] | 72 [60, 79] | 70 [60, 79] | 0/1163 | 73 [61, 80] | 73 [61, 80] |
| Female sex | 0/1852 | 45.0% | 40.8% | 44.8% | 0/1163 | 43.0% | 43.1% |
| Type of admission | 2/1852 | 27/1163 | |||||
| Emergency, surgical | 16.2% | 17.5% | 23.4% | 18.4% | 25.9% | ||
| Emergency, medical | 69.6% | 69.3% | 59.3% | 65.3% | 56.5% | ||
| Planned, surgical | 9.7% | 10.1% | 14.7% | 11.8% | 14.4% | ||
| Planned, medical | 4.5% | 3.2% | 2.7% | 4.4% | 3.1% | ||
| Charlson comorbidity index | 259/1852 | 2 [1, 4] | 2 [1, 4] | 3 [1, 5] | 155/1163 | 3 [1, 4] | 3 [1, 5] |
| Degree of confirmation of infection | 0/1852 | 0/1163 | |||||
| Microbiologically proven | 54.2% | 55.8% | 64.8% | 59.2% | 63.8% | ||
| Other confirmation | 24.2% | 26.5% | 21.0% | 24.9% | 19.3% | ||
| Clinically suspected | 21.5% | 17.7% | 14.2% | 15.9% | 17.0% | ||
| Origin of infection | 4/1852 | 3/1163 | |||||
| Present on admission, nosocomial | 10.8% | 11.9% | 12.1% | 11.6% | 11.8% | ||
| Present on admission, not nosocomial | 54.1% | 46.3% | 43.0% | 43.3% | 42.6% | ||
| Present on admission, unknown origin | 7.2% | 8.4% | 7.6% | 8.0% | 8.1% | ||
| Onset during stay, nosocomial | 19.6% | 23.0% | 25.1% | 26.2% | 25.9% | ||
| Onset during stay, not nosocomial | 3.4% | 4.4% | 5.3% | 3.9% | 4.1% | ||
| Onset during stay, unknown origin | 2.3% | 2.3% | 2.9% | 2.5% | 3.3% | ||
| More than one infection | 2.6% | 3.6% | 4.0% | 4.5% | 4.1% | ||
| Source of infection | |||||||
| Catheter related infection | 146/1852 | 3.8% | 4.2% | 6.3% | 77/1163 | 4.6% | 7.5% |
| Central nervous system infection | 146/1852 | 3.1% | 2.2% | 1.6% | 77/1163 | 2.4% | 1.0% |
| Cardiovascular infection | 146/1852 | 1.2% | 2.0% | 2.8% | 77/1163 | 2.7% | 3.9% |
| Pneumonia | 146/1852 | 39.1% | 56.7% | 59.0% | 77/1163 | 55.5% | 59.8% |
| Other respiratory infections | 146/1852 | 9.1% | 5.6% | 5.4% | 77/1163 | 5.1% | 5.9% |
| Thoracic (empyema/mediastinitis) | 146/1852 | 0.9% | 1.6% | 2.6% | 77/1163 | 2.0% | 2.6% |
| Intraabdominal infection | 146/1852 | 10.9% | 14.6% | 19.0% | 77/1163 | 16.1% | 22.2% |
| Gastrointestinal infection | 146/1852 | 13.1% | 9.7% | 11.0% | 77/1163 | 10.1% | 8.7% |
| Urogenital infection | 146/1852 | 27.5% | 22.0% | 22.2% | 77/1163 | 24.5% | 20.3% |
| Bones/soft tissue infection | 146/1852 | 10.5% | 10.0% | 11.8% | 77/1163 | 10.7% | 11.6% |
| Primary bacteremia | 146/1852 | 6.9% | 8.0% | 7.9% | 77/1163 | 8.4% | 8.9% |
| Other infection | 146/1852 | 2.4% | 1.7% | 1.0% | 77/1163 | 1.1% | 1.1% |
| Treated on ICU | 0/1852 | 43.6% | 65.8% | 92.3% | 0/1163 | 74.0% | 97.1% |
| ICU length-of-stay (days) | 0/1505 | 7 [3, 17] | 9 [4, 19] | 11 [4, 23] | 0/1089 | 9 [4, 21] | 11 [4, 23] |
| Ventilation (including noninvasive) | 35/1852 | 47/1163 | |||||
| No | 66.0% | 46.1% | 19.8% | 38.2% | 13.3% | ||
| < 24 h | 8.9% | 9.9% | 12.0% | 10.5% | 12.1% | ||
| ≥ 24 h | 25.1% | 44.1% | 68.2% | 51.3% | 74.6% | ||
| Extracorporeal membrane oxygenation | 4/1852 | 1.4% | 2.4% | 4.5% | 27/1163 | 3.0% | 5.3% |
| Renal replacement therapy | 7/1852 | 11.3% | 20.2% | 33.4% | 26/1163 | 28.3% | 41.9% |
| Liver replacement therapy | 2/1852 | 0.1% | 0.1% | 0.2% | 25/1163 | 0.2% | 0.3% |
| Vasopressor use | 26/1852 | 30.8% | 51.0% | 82.9% | 45/1163 | 62.4% | 90.6% |
| Tracheotomy | 6/1852 | 5.9% | 10.1% | 16.4% | 29/1163 | 12.2% | 16.2% |
| Hospital length-of-stay (days) | 0/1852 | 11 [6, 23] | 17 [9, 33] | 21 [9, 37] | 0/1163 | 19 [9, 34] | 20 [8, 35] |
Descriptive statistics given as relative frequencies (%) or median [1st quartile, 3rd quartile]. Absolute frequencies are given for the sample, and all descriptive statistics (relative frequency and median) are calculated with adjustment for sampling weights and clustering