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. 2024 Mar 20;331(15):1298–1306. doi: 10.1001/jama.2024.0792

Table 2. Primary Outcomes.

Diagnosis Participants, No. Proportion of participants positive for P-SYN, % (95% CI)
P-SYN positivea P-SYN negativeb
Synucleinopathy 213 10 95.5 (91.9-97.8)
Parkinson disease 89 7 92.7 (85.6-97.0)
Multiple system atrophy 54 1 98.2 (91.7-99.9)
Dementia with Lewy bodies 48 2 96.0 (86.3-99.5)
Pure autonomic failure 22 0 100 (84.6-100)
No synucleinopathy 4 116 3.3 (1.3-8.0)

Abbreviation: P-SYN, phosphorylated α-synuclein.

a

Positive for P-SYN in at least 1 biopsy site.

b

Negative for P-SYN in all biopsy sites.