Table 1 |.
Progenitor population | Human cell surface markers | Mouse cell surface markers |
---|---|---|
Pre-cDCl | CD135, CD117, CD116, CD123low/int, CD45RA, CADM1 (Lineage negativea) | CD135, CD115, CD117int, CD11C, CD226, MHC class IIlow/int (Lineage negativeb,c) |
Pre-cDC2 | CD135, CD117, CD116, CD123low, CD45RA, CD172hi, CD1C (Lineage negativea) | CD135, CD117low, CD11C, Ly6C, ZBTB46 (Lineage negativeb,c) |
Pre-cDC | CD135, CD117, CD116, CD123, CD45RA, CD172int, CD22 (Lineage negativea) | CD11C, CD135, CD172int (Lineage negativeb,c) |
CDP | CD34, CD38, CD135, CD117, CD116, CD123hi, CD45RA (Lineage negativea) | CD135, CD115, CD117int (Lineage negativeb,d) |
MDP | CD34, CD38, CD135, CD117, CD115, CD123 (Lineage negativea) | CD135, CD115, CD117hi (Lineage negativeb,d) |
cMoP | CD34, CD38, CD45RA, CD135, CLEC12A, CD64 | CD135−, CD117, CD115, Ly6C (Lineage negativeb,d) |
GMDP/GMP | CD34, CD38, CD135, CD117, CD123int (Lineage negativea) | CD117, CD34−, CD16/CD32low (Lineage negativeb,d) |
CMP | CD34, CD38, CD135 (Lineage negativea) | CD117, CD34, CD16/CD32low (Lineage negativeb,d) |
CLP | CD34, CD45RA, CD10 (Lineage negativea) | CD135, CD127, CD117int/low (Lineage negativeb,d) |
Pre-pDC | ND | CD135, CD117int/low, CD127, Ly6D, SiglecH, CD81 (Lineage negativeb) |
cDC, classical dendritic cell; cDC1, type 1 classical dendritic cell; cDC2, type 2 classical dendritic cell; CDP, common dendritic cell precursor; CLP, common lymphoid progenitor; cMoP, common monocyte progenitor; CMP, common myeloid progenitor; GMDP, granulocyte–monocyte–dendritic cell progenitor; GMP, granulocyte–monocyte progenitor; MDP, monocyte–dendritic cell progenitor; ND, not determined; pDC, plasmacytoid dendritic cell.
Lineage negative for CD3, CD19, CD20, CD56, CD14, CD66B, CD303, CD335, CD10, CD123, CD1C.
Lineage negative for CD3, CD19, Ly6G, Ter-119, NK1.1, CD105, B220, MHC class II.
Lineage negative for SiglecH, CD127.
Lineage negative for CD5, CD11B, CD8a, CD4, CD127.