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. Author manuscript; available in PMC: 2024 Mar 21.
Published in final edited form as: Nat Rev Immunol. 2020 Sep 9;21(2):101–115. doi: 10.1038/s41577-020-00413-x

Table 1 |.

Markers of human and mouse dendritic cell and monocyte progenitors

Progenitor population Human cell surface markers Mouse cell surface markers
Pre-cDCl CD135, CD117, CD116, CD123low/int, CD45RA, CADM1 (Lineage negativea) CD135, CD115, CD117int, CD11C, CD226, MHC class IIlow/int (Lineage negativeb,c)
Pre-cDC2 CD135, CD117, CD116, CD123low, CD45RA, CD172hi, CD1C (Lineage negativea) CD135, CD117low, CD11C, Ly6C, ZBTB46 (Lineage negativeb,c)
Pre-cDC CD135, CD117, CD116, CD123, CD45RA, CD172int, CD22 (Lineage negativea) CD11C, CD135, CD172int (Lineage negativeb,c)
CDP CD34, CD38, CD135, CD117, CD116, CD123hi, CD45RA (Lineage negativea) CD135, CD115, CD117int (Lineage negativeb,d)
MDP CD34, CD38, CD135, CD117, CD115, CD123 (Lineage negativea) CD135, CD115, CD117hi (Lineage negativeb,d)
cMoP CD34, CD38, CD45RA, CD135, CLEC12A, CD64 CD135, CD117, CD115, Ly6C (Lineage negativeb,d)
GMDP/GMP CD34, CD38, CD135, CD117, CD123int (Lineage negativea) CD117, CD34, CD16/CD32low (Lineage negativeb,d)
CMP CD34, CD38, CD135 (Lineage negativea) CD117, CD34, CD16/CD32low (Lineage negativeb,d)
CLP CD34, CD45RA, CD10 (Lineage negativea) CD135, CD127, CD117int/low (Lineage negativeb,d)
Pre-pDC ND CD135, CD117int/low, CD127, Ly6D, SiglecH, CD81 (Lineage negativeb)

cDC, classical dendritic cell; cDC1, type 1 classical dendritic cell; cDC2, type 2 classical dendritic cell; CDP, common dendritic cell precursor; CLP, common lymphoid progenitor; cMoP, common monocyte progenitor; CMP, common myeloid progenitor; GMDP, granulocyte–monocyte–dendritic cell progenitor; GMP, granulocyte–monocyte progenitor; MDP, monocyte–dendritic cell progenitor; ND, not determined; pDC, plasmacytoid dendritic cell.

a

Lineage negative for CD3, CD19, CD20, CD56, CD14, CD66B, CD303, CD335, CD10, CD123, CD1C.

b

Lineage negative for CD3, CD19, Ly6G, Ter-119, NK1.1, CD105, B220, MHC class II.

c

Lineage negative for SiglecH, CD127.

d

Lineage negative for CD5, CD11B, CD8a, CD4, CD127.