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. Author manuscript; available in PMC: 2024 Mar 21.
Published in final edited form as: Nat Rev Immunol. 2020 Sep 9;21(2):101–115. doi: 10.1038/s41577-020-00413-x

Table 2 |.

Useful models for the definition of dendritic cell ontogeny and function

Gene Expression by Genetic mouse model Refs
cDC1s cDC2s pDCs DC progenitors Reporter Knockout Floxed Cre recombinase Diphtheria toxin receptor
Markers
Itgax + + + + No No No Yes Yes 198203
CIec9a + + + Yes Yes No Yes Yes 45,204
Cd207 + + No No No Yes Yes 205208
SiglecH + + No No No Yes Yes 204,209,210
Xcr1 + Yes Yes Yes Yes Yes 99,211
Karma/Gpr141b + No No No No Yes 212
Clec4a4 No No No No Yes 213
Mgl2 + No No No No Yes 134
Clec4c + No No No No Yes 152
Cx3cr1 + + Yes Yes No No Yes 214,215
IL7r + Yes Yes Yes Yes No 216
Csf2r + Yes Yes Yes Yes No 217219
Transcription factors
Zbtb46 + + + Yes Yes No Yes Yes 6,179,220
Batf3 + + + No Yes No No No 49
Tcf3 + Yes No Yes No No 221
Tcf4 + + No No Yes No No 57
Irf4 + Yes Yes Yes No No 222
Nfil3 + + No Yes Yes No No 50,223
Id2 + + + No No Yes No No 48,224,225
Klf4 + No No Yes No No 144,226
Zeb2 + + + No No Yes No No 55,56,227
Irf8 + + + + No Yes Yes No No 228,229
Irf8 + 32 kb + + No Yes No No No 53
Irf8 + 41 kb + + + No Yes No No No 53

cDC1, type 1 classical dendritic cell; cDC2, type 2 classical dendritic cell; DC dendritic cell; pDC, plasmacytoid dendritic cell.