Table 2 |.
Useful models for the definition of dendritic cell ontogeny and function
| Gene | Expression by | Genetic mouse model | Refs | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| cDC1s | cDC2s | pDCs | DC progenitors | Reporter | Knockout | Floxed | Cre recombinase | Diphtheria toxin receptor | ||
| Markers | ||||||||||
| Itgax | + | + | + | + | No | No | No | Yes | Yes | 198–203 |
| CIec9a | + | − | + | + | Yes | Yes | No | Yes | Yes | 45,204 |
| Cd207 | + | + | − | − | No | No | No | Yes | Yes | 205–208 |
| SiglecH | − | − | + | + | No | No | No | Yes | Yes | 204,209,210 |
| Xcr1 | + | − | − | − | Yes | Yes | Yes | Yes | Yes | 99,211 |
| Karma/Gpr141b | + | − | − | − | No | No | No | No | Yes | 212 |
| Clec4a4 | − | − | − | − | No | No | No | No | Yes | 213 |
| Mgl2 | − | + | − | − | No | No | No | No | Yes | 134 |
| Clec4c | − | − | + | − | No | No | No | No | Yes | 152 |
| Cx3cr1 | − | + | − | + | Yes | Yes | No | No | Yes | 214,215 |
| IL7r | − | − | − | + | Yes | Yes | Yes | Yes | No | 216 |
| Csf2r | − | − | − | + | Yes | Yes | Yes | Yes | No | 217–219 |
| Transcription factors | ||||||||||
| Zbtb46 | + | + | − | + | Yes | Yes | No | Yes | Yes | 6,179,220 |
| Batf3 | + | + | − | + | No | Yes | No | No | No | 49 |
| Tcf3 | − | − | − | + | Yes | No | Yes | No | No | 221 |
| Tcf4 | − | − | + | + | No | No | Yes | No | No | 57 |
| Irf4 | − | + | − | − | Yes | Yes | Yes | No | No | 222 |
| Nfil3 | + | − | − | + | No | Yes | Yes | No | No | 50,223 |
| Id2 | + | + | − | + | No | No | Yes | No | No | 48,224,225 |
| Klf4 | − | + | − | − | No | No | Yes | No | No | 144,226 |
| Zeb2 | − | + | + | + | No | No | Yes | No | No | 55,56,227 |
| Irf8 | + | + | + | + | No | Yes | Yes | No | No | 228,229 |
| Irf8 + 32 kb | + | − | − | + | No | Yes | No | No | No | 53 |
| Irf8 + 41 kb | + | − | + | + | No | Yes | No | No | No | 53 |
cDC1, type 1 classical dendritic cell; cDC2, type 2 classical dendritic cell; DC dendritic cell; pDC, plasmacytoid dendritic cell.