Table 2.
Sensitivity of point-of-care screening tests when used with specimens from participants with HIV infection by acute HIV infection status at time of study visit, Project DETECT, Seattle WA US, September 2015- September 2017.
| POC test and specimen type | Specimens from participants with HIV infection (n = 179) | Specimens from participants with HIV infection, excluding those with AHI (n = 173) | ||||
|---|---|---|---|---|---|---|
| TP | Sensitivity % (95 % CI) | p-valuea | TP | Sensitivity % (95 % CI) | p-valuea | |
| DPP OF | 161 | 89.94 (84.57–93.93) | 0.0002 | 161 | 93.06 (88.20–96.36) | 0.001 |
| DPP WB | 171 | 95.53 (91.38–98.05) | 0.250 | 171 | 98.84 (95.89–99.86) | > 0.999 |
| OraQuick OF | 165 | 92.18 (87.23–95.66) | 0.012 | 165 | 95.38 (91.09–97.98) | 0.039 |
| OraQuick WB | 172 | 96.09 (92.11–98.41) | 0.500 | 172 | 99.42 (96.82–99.99) | > 0.999 |
| INSTI WB | 173 | 96.65 (92.85–98.76) | > 0.999 | 172 | 99.42 (96.82–99.99) | > 0.999 |
| Determine WB | 174 | 97.21 (93.60–99.09) | ref | 172 | 99.42 (96.82–99.99) | ref |
Abbreviations: POC, point of care; AHI, acute HIV infection; TP, true positive; DPP, DPP HIV1/2 Assay; OraQuick, OraQuick Advance HIV-1/2; INSTI, INSTI HIV-1/HIV-2 Rapid Antibody Test; Determine, Determine HIV-1/2 Ag/Ab Combo; OF, oral fluid; WB, whole blood.
Footnotes:
a
Compared to Determine performed on whole blood using McNemar’s test.